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MedPage Today Dermatology - Recent Medical Updates

Delgocitinib Cream More Effective Than Oral Alitretinoin for Severe Hand Eczema
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115277.jpg"/> (MedPage Today) -- Delgocitinib cream had superior efficacy and a better safety profile compared with oral alitretinoin for the treatment of severe chronic hand eczema, the randomized phase III DELTA FORCE trial showed. Among over 500 patients...


No Extra Cancer Recurrence Risk Seen for RA Patients on Biologic Therapy
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115250.jpg"/> (MedPage Today) -- Rheumatoid arthritis (RA) patients in Denmark with a history of solid tumor cancers, now in remission, faced no greater likelihood of cancer relapse when they were treated with biologic agents, compared with conventional disease...


FDA Approves New Option for Chronic Hives
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115194.jpg"/> (MedPage Today) -- The FDA approved dupilumab (Dupixent) for chronic spontaneous urticaria (CSU) in patients 12 years and older, the first new targeted drug for the inflammatory skin disease in over a decade, drugmakers Regeneron and Sanofi announced...


Phototherapy Promising as Add-On to Oral Ritlecitinib for Vitiligo
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115187.jpg"/> (MedPage Today) -- Adding narrowband ultraviolet B (UVB) phototherapy to oral treatment with ritlecitinib (Litfulo) enhanced repigmentation in patients with nonsegmental vitiligo compared with the drug alone, exploratory analysis of a phase IIb...


Detectable ctDNA Before Adjuvant Therapy for Melanoma May Predict Recurrence
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115153.jpg"/> (MedPage Today) -- Droplet digital PCR measurements of circulating tumor (ct)DNA to assess minimal residual disease before the initiation of adjuvant therapy and during follow-up for patients with resected stage III melanoma may accurately identify...


Read the Results of Trump's 2025 Physical Exam
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115125.jpg"/> (MedPage Today) -- On April 11, 2025, President Donald J. Trump underwent his annual physical examination at Walter Reed National Military Medical Center. I performed and supervised the comprehensive exam, which included diagnostic and laboratory...


RFK Jr. Praises Anti-Vax Docs; EPA to Probe Fluoride 'Risks'; AI for Skin Cancer Dx
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115005.jpg"/> (MedPage Today) -- Note that some links may require registration or subscription. MedPage Today is collecting stories of HHS staffers across all agencies affected by Trump administration cuts. If you want to share your story, please email MPT_Editorial...


Newer Biologics Tied to Fewer Infections for Older Patients With Psoriatic Disease
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114768.jpg"/> (MedPage Today) -- Biologics targeting interleukin (IL)-12, IL-23, and IL-17 were associated with a lower rate of serious infections among older adults with psoriatic disease, a Canadian cohort study showed. For more than 11,000 older adults started...


This Cutting-Edge Treatment for Alopecia Is a Repurposed Drug From the 1990s
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114730.jpg"/> (MedPage Today) -- The latest trend in treating hair loss may sound familiar -- essentially, it's a repurposed drug first popularized in the 1990s. Back then, TV viewers were inundated with ads for Rogaine, a sticky topical solution that could...


Make the Diagnosis: Pink Plaques and Patchy Hair Loss Suggest Which Disorder?
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114726.jpg"/> (MedPage Today) --


Experts Sound the Alarm on Pricey Skin Substitutes in Wound Care Industry
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114717.jpg"/> (MedPage Today) -- The runaway costs of skin substitutes for treating chronic wounds have experts and accountable care organizations (ACOs) sounding the alarm, and new rules targeting profiteering in the industry are now in limbo under the Trump...


Hair Loss: Another Wegovy Side Effect?
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114702.jpg"/> (MedPage Today) -- A preprint study suggested that GLP-1 receptor agonists may be associated with hair loss, though only in women. Using a random sample of 16 million patients, researchers found that women who newly initiated semaglutide (Ozempic...


Spironolactone Gains Foothold in Acne Amid Unresolved Safety Questions
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114693.jpg"/> (MedPage Today) -- With spironolactone (Aldactone) treatment for acne rising several-fold in recent decades, safety concerns persist for this off-label practice in understudied populations. A database of U.S. insurance claims showed that among...


Longtime Congressman Dies; Acne Creams Recalled; Did Dr. Oz Avoid Medicare Taxes?
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114650.jpg"/> (MedPage Today) -- Note that some links may require registration or subscription. MedPage Today is collecting stories of HHS staffers across all agencies affected by Trump administration cuts. If you want to share your story, please email MPT_Editorial...


Rapid Improvement in Atopic Dermatitis With Dual JAK/TYK2 Inhibitor
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114634.jpg"/> (MedPage Today) -- ORLANDO -- More than 80% of patients with moderate or severe atopic dermatitis (AD) had at least 75% improvement after 12 weeks of treatment with an investigational dual-target small-molecule inhibitor, according to a study...


Topical JAK Inhibitor Active in Itchy Prurigo Nodularis
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114594.jpg"/> (MedPage Today) -- ORLANDO -- More than 40% of patients with longstanding prurigo nodularis (PN) had significant improvement within 3 months of starting topical ruxolitinib (Opzelura), according to a study reported here. After 12 weeks of treatment...


TYK2 Inhibitor Scores Two Wins Outside Plaque Psoriasis
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114579.jpg"/> (MedPage Today) -- ORLANDO -- The TYK2 inhibitor deucravacitinib (Sotyktu) showed clinical potential in two diseases other than psoriasis, according to studies reported here. More than half of patients with psoriatic arthritis (PsA) had at least...


T-Cell Rebalancing Therapy Active in Previously Treated Atopic Dermatitis
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114570.jpg"/> (MedPage Today) -- ORLANDO -- A novel therapy for atopic dermatitis (AD) led to at least 75% improvement in a third of patients after 6 months, a placebo-controlled trial showed. Including patients who used topical rescue medication, almost...


Rapid, Substantial Psoriasis Improvement With Oral IL-23 Inhibitor
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114558.jpg"/> (MedPage Today) -- ORLANDO -- Two-thirds of patients with moderate or severe plaque psoriasis had complete or nearly complete clearance at 4 months with an oral peptide targeting interleukin (IL)-23, a randomized study showed. The primary analysis...


Humira Copycats for Psoriasis Backed by Real-World Outcomes
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114532.jpg"/> (MedPage Today) -- Two adalimumab biosimilars (Amjevita and Imraldi) worked as well for moderate to severe psoriasis as the original brand-name product (Humira) for patients either starting or switching treatment, according to real-world data from...


Biologic May Spark Catch-Up Growth in Kids With Eczema
<img src="https://clf1.medpagetoday.com/media/images/114xxx/114498.jpg"/> (MedPage Today) -- SAN DIEGO -- Biologic treatment for atopic dermatitis appeared to improve growth trajectories for younger children, a trial analysis showed. Over the course of 16 weeks of treatment in the pivotal randomized trials, children...