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MedPage Today Hematology/Oncology - Recent Medical Updates

Cervical Artery Dissection and Stroke; Preventing Clotting in Cancer Patients
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115296.jpg"/> (MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center...


Modified FLOT Beats FOLFOX for Advanced Gastric Cancer
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115293.jpg"/> (MedPage Today) -- A modified FLOT regimen (fluorouracil, oxaliplatin, and docetaxel; TFOX) outperformed a standard chemotherapy triplet for the first-line treatment of advanced HER2-negative gastric cancer, a phase III trial showed. In the more...


Blood Cancer Data Ignore Sex; Cancer Biosimilars Take Off; Mixed Prevention News
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115283.jpg"/> (MedPage Today) -- In a review of 182 cancer studies, authors failed to report outcome data by sex in 90% of cases, even though men develop hematologic malignancies more often than women and the diseases progress differently in the sexes. (British...


New PD-1 Inhibitor Approved for Nasopharyngeal Carcinoma
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115270.jpg"/> (MedPage Today) -- The FDA approved the PD-1 inhibitor penpulimab, with two indications, for treating non-keratinizing nasopharyngeal carcinoma (NPC) in adults. No trade name was indicated for the drug. The first indication -- for the first...


Tumor-Infiltrating Clonal Hematopoiesis Increased Risk of Poor Outcomes in Cancer
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115254.jpg"/> (MedPage Today) -- Tumor-infiltrating clonal hematopoiesis (TI-CH) increased the risk of disease recurrence or death among patients with early non-small cell lung cancer (NSCLC), and the risk of death from any cause among patients with solid tumors...


No Extra Cancer Recurrence Risk Seen for RA Patients on Biologic Therapy
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115250.jpg"/> (MedPage Today) -- Rheumatoid arthritis (RA) patients in Denmark with a history of solid tumor cancers, now in remission, faced no greater likelihood of cancer relapse when they were treated with biologic agents, compared with conventional disease...


BTK Inhibitors for Follicular Lymphoma
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115248.jpg"/> (MedPage Today) -- Newer-generation Bruton's tyrosine kinase (BTK) inhibitors have found a place in the management of follicular lymphoma, a malignancy where the first-generation drug ibrutinib (Imbruvica) failed. "When the first BTK inhibitor...


High Response Rate in Myeloma With Novel CAR-T After Anti-BCMA Failure
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115242.jpg"/> (MedPage Today) -- More than 80% of patients whose multiple myeloma had progressed on standard chimeric antigen receptor (CAR) T-cell therapy responded to an investigational CAR T-cell agent, a small study from China showed. Targeting the GPRC5D...


Advanced Cancers Returned to Prepandemic Levels, According to a Reassuring Report
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115220.jpg"/> (MedPage Today) -- Many Americans were forced to postpone cancer screenings -- colonoscopies, mammograms, and lung scans -- for several months in 2020 as COVID-19 overwhelmed doctors and hospitals. But that delay in screening isn't making...


FDA Suspends Milk Testing; New NIH Grant Rules; ICE Detains Cancer Researcher
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115219.jpg"/> (MedPage Today) -- Note that some links may require registration or subscription. MedPage Today is collecting stories of HHS staffers across all agencies affected by Trump administration cuts. If you want to share your story, please email MPT_Editorial...


SCOTUS Gives Mixed Signals on ACA's Preventive Care Coverage Mandate
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115218.jpg"/> (MedPage Today) -- The word "independence" was heavily featured in Monday's oral argument before the Supreme Court on a case questioning the legitimacy of the Affordable Care Act (ACA) requirement that insurers cover certain preventive services...


Women Don't Want AI as Sole Reader of Breast Cancer Screenings
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115213.jpg"/> (MedPage Today) -- Few women wanted artificial intelligence (AI) as the sole reader of their screening mammograms, according to a survey, though most respondents generally supported some use of the technology. Among more than 500 women who presented...


Is Lung Cancer Screening as Effective Without Risk-Based Selection?
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115209.jpg"/> (MedPage Today) -- Low-dose CT (LDCT) screening for lung cancer in an all-comer Chinese population ages 40 to 74 identified at least as many cases as would be expected from screening high-risk individuals, a study found. One-time screening flagged...


I'm in Medical School to Practice Healthcare Not 'Sick Care'
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115205.jpg"/> (MedPage Today) -- America does not have a healthcare system. I pulled back the curtain and saw a woman in her early 60s lying in the hospital bed. She looked emaciated -- sunken eyes, a thin, narrow face, and quick, shallow breaths. Her husband...


SCOTUS to Mull Whether Insurers Must Offer Certain Preventive Services for Free
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115201.jpg"/> (MedPage Today) -- The Supreme Court will hear oral arguments Monday in a case that could affect what kind of preventive care is covered at no charge under Americans' health insurance plans. The case, known as Kennedy v. Braidwood, involves Christian...


Encouraging Results After Discontinuation of Cancer Immunotherapy Due to Immune AEs
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115200.jpg"/> (MedPage Today) -- Patients who discontinued cancer immunotherapy because of immune-related adverse events (irAEs) often had durable benefits despite not receiving the planned course of treatment, a retrospective study of patients with lung cancer...


Sexual Toxicity of Cancer Drugs; Guilt and Non-Beneficial Care; Effects of Cannabis
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115196.jpg"/> (MedPage Today) -- Cancer drugs' sexual toxicity warrants a "call to action" among oncologists to address the problem. (Lancet Oncology) U.S. medical centers have appealed to the FDA for compassionate use approval of the adenosine receptor inhibitor...


Hydroxyurea Remains Effective Long-Term in Children With Sickle Cell Disease
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115191.jpg"/> (MedPage Today) -- Hydroxyurea, a myelosuppressive agent that has been a standard treatment in sickle cell disease (SCD) for decades, remains effective over the long term in children with the disease, according to a single-center, real-world study...


Beyond Ivy League, RFK Jr.'s NIH Slashed Funding Across States That Backed Trump
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115182.jpg"/> (MedPage Today) -- The NIH's sweeping cuts of grants that fund scientific research are inflicting pain almost universally across the U.S., including in most states that backed President Trump in the 2024 election. A KFF Health News analysis underscores...


Honing Indications for Endocrine Therapy in ER-Low Early Breast Cancer
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115154.jpg"/> (MedPage Today) -- Omission of endocrine therapy in estrogen receptor (ER)-low early breast cancer had a significant association with worse survival, particularly in patients with residual disease after neoadjuvant chemotherapy (NAC), a large retrospective...


Detectable ctDNA Before Adjuvant Therapy for Melanoma May Predict Recurrence
<img src="https://clf1.medpagetoday.com/media/images/115xxx/115153.jpg"/> (MedPage Today) -- Droplet digital PCR measurements of circulating tumor (ct)DNA to assess minimal residual disease before the initiation of adjuvant therapy and during follow-up for patients with resected stage III melanoma may accurately identify...