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AXA
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Go further with international health insurance. Global support for people who think a little bigger
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The Apollonion Private Hospital is an ultra-modern Hospital purposely built to offer the best medical care to its patients.
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Durbin
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Specialist medical suppliers in sourcing and distributing pharmaceuticals, medical equipment and consumable supplies.
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Self
self.com
Women Magazine on Fitness, Health, Food, Beauty & more.
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Easyway
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Allen Carr Easyway International operates clinics in more than 150 cities in over 50 countries worldwide.
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id Hospital
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All kinds of plastic surgeries at affordable cost.
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UT Health
uthealtheasttexas.com
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WORLD HOSPITAL DIRECTORY
Research Medical Molecular Human Reproduction - current issue
<span class="paragraphSection">This is a correction to: Yuying Zhang, Lingtao Yang, Dongyong Yang, Songchen Cai, Yanjun Wang, Linlin Wang, Yuye Li, Longfei Li, Tailang Yin, Lianghui Diao, Understanding the heterogeneity of natural killer cells at the maternal–fetal interface: implications for pregnancy health and disease, <span style="font-style:italic;">Molecular Human Reproduction</span>, Volume 30, Issue 11, November 2024, gaae040, <a href="https://doi.org/10.1093/molehr/gaae040">https://doi.org/10.1093/molehr/gaae040</a></span>
<span class="paragraphSection"><div class="boxTitle">Abstract</div>The activation of dormant primordial follicles is a promising method to improve the fertility of premature ovarian insufficiency (POI) patients. Many experiments from both human and animal studies suggest that human platelet-rich plasma (hPRP) may restore ovarian function and promote follicle growth. However, the underlying mechanisms remain unclear. In the current study, our results demonstrate that hPRP significantly increased the number of growing follicles and promoted the proliferation of granulosa cells in cultured mouse ovaries. hPRP also significantly increased the protein levels of phosphorylated protein kinase B (p-Akt) and forkhead box O3a (p-FOXO3a), as well as the number of oocytes with FOXO3a nuclear export in cultured mouse ovaries. Immunofluorescence results showed that <span style="font-style:italic;">in vitro</span> treatment with hPRP significantly increased the fluorescence intensity of p-Akt in oocytes. The inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway by LY294002 blocked the hPRP-induced increase in the number of growing follicles in cultured mouse ovaries. Furthermore, hPRP injected i.p. or added to the medium significantly increased the number of growing follicles and the protein levels of p-Akt in the ovaries of newborn mice and in cultured human ovarian tissues. Taken together, our findings from mouse and human experiments indicate that hPRP promotes the activation of primordial follicles through the PI3K/Akt signaling pathway in oocytes.</span>
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